反应详情

The following compounds are prepared essentially as described in Example 5 using (6-bromo-pyridin-2-yl)-dimethyl-amine and either (1R,2R)-2-methyl-cyclopropanecarboxylic acid [4-bromo-3-(2-ethyl-2H-indazol-5-yl)-isothiazol-5-yl]-amide or (1R,2R)-2-methyl-cyclopropanecarboxylic acid [4-bromo-3-(2-methyl-2H-indazol-5-yl)-isothiazol-5-yl]-amide. Example 7; is prepared as the free base by omitting treatment with hydrogen chloride.

1. customThe following compounds are prepared essentially
2. customis prepared as the free base