反应详情

To ethyl 2-[5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]pyrimidine-5-carboxylate (0.345 g, 0.9 mmol) was added 4M HCl in dioxane (2 ml, 8 mmol). The mixture was stirred at r.t. for 1 h, then evaporated to dryness. The residue was dissolved in methanol, loaded onto a SCX-2 cartridge, washed with methanol (100 ml), then eluted with 2M ammonia in methanol to give the title compound (0.285 g, 100%). LCMS purity >95%, m/z 263 [M+H]+.

1. customevaporated to dryness
2. dissolutionThe residue was dissolved in methanol
3. washwashed with methanol (100 ml)
4. washeluted with 2M ammonia in methanol