Hydrochloric Acid → 6-(5-Naphthalen-2-ylmethyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)pyridine-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a suspension of ethyl 6-(5-naphthalen-2-ylmethyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)pyridine-5-carboxamide (0.255 g, 0.63 mmol) in EtOH (2 ml) was added 6M NaOH (2 ml, 12 mmol). The mixture was heated at 80° C. for 90 min and then cooled to r.t. Concentrated HCl was then added until a precipitate formed, and the solid was collected by filtration (240 mg, quant.). The compound was carried onto the next step without characterization.

Provenance & Evidence