Picolyl chloride hydrochloride → HCID 44192408, compound

HRID 2079841Notes

Reaction equation

HRID 2079841 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]3[N:11]=[C:12]4[C:18]([C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:17][N:16](COCC[Si](C)(C)C)[C:13]4=[N:14][CH:15]=3)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C(O[C:38]([N:40]1CCC(OS(C)(=O)=O)[CH2:42][CH2:41]1)=O)(C)(C)C.Cl.Cl[CH2:53][C:54]1C=CC=CN=1>>[CH3:21][C:20]([CH3:23])([CH3:22])[C:19]([C:18]1[C:12]2[C:13](=[N:14][CH:15]=[C:10]([C:6]3[CH:7]=[C:2]4[C:3]([CH:53]=[CH:54][N:1]4[CH:9]4[CH2:8][CH2:38][NH:40][CH2:41][CH2:42]4)=[CH:4][CH:5]=3)[N:11]=2)[NH:16][CH:17]=1)=[O:24]

Participants

4

Reactant 3

HCID 23392Picolyl chloride hydrochlorideHCID 41848691-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidineHCID 57829224HCID 57829224, compound

Product 1

HCID 44192408HCID 44192408, compound

Procedure

Substituting 1-[2-(1H-indol-6-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one for 1-[2-(1H-indol-5-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one and 4-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester for 2-chloromethylpyridine hydrochloride. MP=201-207 C., (M+H)+=402.

Sources & evidence

ORD record
ord-01d9d5bcad2a41e48d337ed784560fab
Source dataset
uspto-grants-2011_04
Patent number
US07932254B2

Reaction notes

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