Tricalcium Phosphate → L-(-)-Ornithine

Participants

Reaction Steps

A mixture of 136.2 Kg of ornithine hydrochloride (Commercial name: L-ornithine hydrochloride, Kyowa Hakko Co., Ltd.), 36.0 Kg of a fine cellulose crystal (Commercial name: Avcel FD101, Asahi Kaei Chemicals Co., Ltd.); 6.6 kg of sucrose fatty acid ester (Commercial name: DK ester F-20W, Daiichi Kogyo Seiyaku Co., Ltd.); 1.2 kg of calcium phosphate (Commercial name: Tricalcium phosphate, Taihei Chemical Industrial Co., Ltd.); and 20.0 kg of β-cyclodextrin (Commercial name: Seldex B-100, Nihon Shokuhinkako Co., Ltd.) was mixed using a conical blender (CB-1220 Blender, Nihon Kansoki C., Ltd.). The mixture obtained was compressed and molded to a tablet of 250 mg with 8 mm of diameter under 10 KN of compression-molding pressure using the rotary compression molding machine (VIRGO0524SS1AY, Kikusui Seisakusho Co., Ltd.).

Provenance & Evidence