Tricalcium Phosphate → L-(-)-Ornithine

HRID 2079918Notes

Reaction equation

Cl.[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][CH2:6][NH2:7].P([O-])([O-])([O-])=O.[Ca+2].P([O-])([O-])([O-])=O.[Ca+2].[Ca+2].C(O)[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO>>[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][CH2:6][NH2:7]

Participants

Reactant 3

HCID 24456Tricalcium Phosphate

HCID 76654Ornithine hydrochloride

HCID 444041beta-Cyclodextrin

Product 1

HCID 6262L-(-)-Ornithine

Procedure

A mixture of 136.2 Kg of ornithine hydrochloride (Commercial name: L-ornithine hydrochloride, Kyowa Hakko Co., Ltd.), 36.0 Kg of a fine cellulose crystal (Commercial name: Avcel FD101, Asahi Kaei Chemicals Co., Ltd.); 6.6 kg of sucrose fatty acid ester (Commercial name: DK ester F-20W, Daiichi Kogyo Seiyaku Co., Ltd.); 1.2 kg of calcium phosphate (Commercial name: Tricalcium phosphate, Taihei Chemical Industrial Co., Ltd.); and 20.0 kg of β-cyclodextrin (Commercial name: Seldex B-100, Nihon Shokuhinkako Co., Ltd.) was mixed using a conical blender (CB-1220 Blender, Nihon Kansoki C., Ltd.). The mixture obtained was compressed and molded to a tablet of 250 mg with 8 mm of diameter under 10 KN of compression-molding pressure using the rotary compression molding machine (VIRGO0524SS1AY, Kikusui Seisakusho Co., Ltd.).

Workup

customThe mixture obtained

Sources & evidence

ORD record: ord-74422214541f4e179973c734a6db7a54
Source dataset: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07932288B2

Reaction notes

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