Hydrochloric Acid → 115271-79-9

HRID 2079981Notes

Reaction equation

HRID 2079981 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[C:8]2[CH2:15][CH2:14][CH2:13][C:9]2=[N:10][C:11]=1[NH2:12])=[O:5])C.[OH-].[Na+].Cl>C(O)C>[NH2:12][C:11]1[N:10]=[C:9]2[CH2:13][CH2:14][CH2:15][C:8]2=[CH:7][C:6]=1[C:4]([OH:5])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13194076HCID 13194076, compound

Product 1

HCID 54595024115271-79-9Yield 83%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

2-Amino-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxylic acid ethyl ester (0.2 g, 0.97 mmol) described in Preparation Example C-4 was dissolved in ethanol (15 mL), an aqueous solution of 1N sodium hydroxide (7.5 mL) was added thereto, followed by heating at 100° C. for 30 minutes. The reaction solution was allowed to room temperature, then cooled on an ice bath, and neutralized with 1N hydrochloric acid. The precipitated solid was collected by filtration, rinsed with water, then dried, and the title compound (143 mg, 0.8 mmol, 83%) was obtained.

Workup

  1. customwas allowed to room temperature
  2. temperaturecooled on an ice bath
  3. filtrationThe precipitated solid was collected by filtration
  4. washrinsed with water
  5. customdried

Sources & evidence

ORD record
ord-bff47f3cb618418083a0dddb84e88deb
Source dataset
uspto-grants-2011_04
Patent number
US07932272B2

Reaction notes

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