反应详情

A mixture of the resulting quinoline-6-carboxylic acid 4-benzyloxy-benzylamide (310 mg, 0.84 mmol), 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulphide (Lawesson's reagent) (1.4 g, 3.4 mmol) and tetrahydrofuran (10 mL) was refluxed for 1 hour. After cooling, the solvent was evaporated in vacuo, dichloromethane was added to the residue, which was purified by NH silica gel column chromatography (hexane:ethyl acetate=1:1), and the title compound (55 mg, 0.14 mmol, 17%) was obtained as a pale yellow solid.

1. temperaturewas refluxed for 1 hour
2. temperatureAfter cooling
3. customthe solvent was evaporated in vacuo, dichloromethane
4. additionwas added to the residue, which
5. customwas purified by NH silica gel column chromatography (hexane:ethyl acetate=1:1)