(2-Aminopyridin-3-yl)methanol → 3-Pyridinecarboxaldehyde, 2-amino-

HRID 2079999Notes

Reaction equation

HRID 2079999 reaction equation
[NH2:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[CH:4][N:3]=1>[O-2].[O-2].[Mn+4].ClCCl>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 1

HCID 11159325(2-Aminopyridin-3-yl)methanol

Product 1

HCID 7376333-Pyridinecarboxaldehyde, 2-amino-Yield 83%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a mixture of (2-aminopyridin-3-yl)-methanol described in Preparation Example J-3 (130 mg, 1.1 mmol) and dichloromethane (10 mL) was added manganese dioxide (1.3 g, 15 mmol) at room temperature, and the solution was stirred overnight. The reaction solution was filtered through Celite pad, then, the solvent was evaporated in vacuo, and the title compound (108 mg, 0.88 mmol, 83%) was obtained as a white solid.

Workup

  1. filtrationThe reaction solution was filtered through Celite pad
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-b51b7214b3e649b3b4d7c8d3e42ae9c1
Source dataset
uspto-grants-2011_04
Patent number
US07932272B2

Reaction notes

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