Water → HCID 23130682, compound

HRID 2080064Notes

Reaction equation

HRID 2080064 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1([NH:13][CH2:14][C:15]2[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O>O1CCCC1>[NH2:20][CH2:19][C:18]1[CH:21]=[CH:22][C:15]([CH2:14][NH:13][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1114846837812-49-0HCID 21226445Aluminium lithium hydride

Product 1

HCID 23130682HCID 23130682, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Next, to a solution of lithium aluminum hydride (0.91 g, 24 mmol) in tetrahydrofuran (60 mL) was added a solution of the resulting 4-phenylaminomethyl-benzonitrile (2.0 g, 9.61 mmol) in tetrahydrofuran (5 mL), and the solution was stirred at room temperature for 2 hours. Water was added to the reaction solution, which was then extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and the solvent was evaporated to obtain the title compound (1.98 g, 97%) as a yellow oil. This compound was used in the next reaction without purification.

Workup

  1. extractionwas then extracted with ethyl acetate
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-e91aeb5823c2405ead7cad30ca605678
Source dataset
uspto-grants-2011_04
Patent number
US07932272B2

Reaction notes

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