Trifluoroacetic acid → HCID 23130347, compound

HRID 2080197Notes

Reaction equation

HRID 2080197 reaction equation
F[C:2]([F:7])(F)[C:3](O)=O.[NH2:8][C:9]1[N:30]=[C:29](Cl)[CH:28]=[CH:27][C:10]=1[C:11]([NH:13][CH2:14][C:15]1[S:16][C:17]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:18][CH:19]=1)=[O:12]>>[NH2:8][C:9]1[N:30]=[C:29]([NH:8][CH2:9][C:10]2[CH:27]=[CH:28][C:2]([F:7])=[CH:3][CH:11]=2)[CH:28]=[CH:27][C:10]=1[C:11]([NH:13][CH2:14][C:15]1[S:16][C:17]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:18][CH:19]=1)=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 231304982-aminochloro-N-(5-phenoxy-thiophen-2-ylmethyl)-nicotinamide

Product 1

HCID 23130347HCID 23130347, compoundYield 16%

Procedure

The title compound (10.6 mg, 0.0188 mmol, 16%) was obtained as a trifluoroacetic acid salt from 2-amino-chloro-N-(5-phenoxy-thiophen-2-ylmethyl)-nicotinamide described in Example A-101 (41 mg, 0.12 mmol) and 4-fluorobenzylamine (200 μl, 1.75 mmol) according to an analogous method to Example A-94.

Sources & evidence

ORD record
ord-1bff0c2ddd8b464d9c5ad5fe2fce2a46
Source dataset
uspto-grants-2011_04
Patent number
US07932272B2

Reaction notes

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