HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Ethyl Ketone → 2-Methyl-2-(1-pyrrolidinyl)butanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Ethyl Ketone | HCID 6569 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-Methyl-2-(pyrrolidin-1-yl)propanenitrile | HCID 12570647 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Methyl-2-(1-pyrrolidinyl)butanenitrile | HCID 43802838 | 63% |
Reaction Steps
The title compound (9.6 g, 63%) was prepared from pyrrolidine (8.35 ml, 0.1 mol), 2-butanone (8.96 g, 0.1 mol) and potassium cyanide (6.51 g, 0.1 mol) in water (50 ml) in a similar manner to that described in D4. 1H NMR (CDCl3) δ: 1.06 (3H, t, J=7.2 Hz), 1.45 (3H, s), 1.66-1.93 (6H, m), 2.70-2.75 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-fdeac761ed134756b5116e11b959d866 |
| Source note | uspto-grants-2010_06 |