反应详情

To a solution of (R)-tert-butyl 2-((6-(2-cyanophenyl)-2-(3-fluorophenethylamino)nicotinamido)methyl)pyrrolidine-1-carboxylate (680 mg, 1.25 mmol) in MeOH (20 mL) was added HCl (2.0 mL, 8 mmol, 4 M in dioxane). The reaction was stirred at r.t. for 2 h. LC/MS indicated the reaction was complete. The reaction mixture was concentrated under reduced pressure to give 6-(2-cyanophenyl)-2-(3-fluorophenethylamino)-N-(pyrrolidin-2-ylmethyl)nicotinamide hydrochloride which was used for next step without further purification. LRMS (M+H+) m/z 444.2.

1. concentrationThe reaction mixture was concentrated under reduced pressure