HCID 57542646, Verbindung → HCID 57542875, Verbindung

HRID 2080290Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2080290
[N:1]([CH2:4][C@H:5]1[CH2:9][CH2:8][C:7](=[O:10])[N:6]1[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][C@H:5]1[CH2:9][CH2:8][C:7](=[O:10])[N:6]1[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:19])([CH3:18])[CH3:20]

Komponenten

4

Edukt 1

HCID 57542646HCID 57542646, Verbindung

Produkt 1

HCID 57542875HCID 57542875, VerbindungAusbeute 65,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To (R)-tert-butyl 3-(2-(azidomethyl)-5-oxopyrrolidin-1-yl)propylcarbamate (300 mg, 1.01 mmol) in MeOH was added Pd/C. The mixture was the placed into an autoclave, degasses three times, charged with 30 psi of H2 and stirred at rt for 30 min. The mixture was the filtered and the filtrate was concentrated under reduced pressure to give (R)-tert-butyl 3-(2-(aminomethyl)-5-oxopyrrolidin-1-yl)propylcarbamate (180 mg of crude). LRMS (M+H+) m/z 198.1.

Aufarbeitung

  1. additioncharged with 30 psi of H2
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8fcca4533c7b46c4b118a28a3fc48d37
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932270B2

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