HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Ethyl Ketone → 2-(Dimethylamino)-2-methylbutanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Ethyl Ketone | HCID 6569 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 1-(Dimethylamino)cyclopentanecarbonitrile | HCID 10773049 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(Dimethylamino)-2-methylbutanenitrile | HCID 233394 | 78% |
Reaction Steps
The title compound (9.95 g, 78%) was prepared from dimethylamine hydrochloride (8.15 g, 0.1 mol), 2-butanone (8.96 ml, 0.1 mol) and potassium cyanide (6.51 g, 0.1 mol) in water (50 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.00 (3H, t, J=7.2 Hz), 1.43 (3H, s), 1.75-1.87 (2H, m), 2.33 (6H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-feda3fe98f2649c7b3125abf4becb93a |
| Source note | uspto-grants-2010_06 |