反应详情

To an ethanol (8 ml) solution of methyl 3-[6-(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl-5-fluoropyridin-3-yl]propionate (387 mg, 0.80 mmol) was added a 1N aqueous sodium hydroxide solution (4 ml). The resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was acidified with 1N hydrochloric acid, followed by extraction with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure. The residue thus obtained was washed with a mixed solvent of diethyl ether and hexane and then collected by filtration to give the title compound (349 mg, 0.74 mmol, 93%) as a white solid.

1. extractionfollowed by extraction with dichloromethane
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. filtrationfiltered
4. concentrationThe filtrate was concentrated under reduced pressure
5. customThe residue thus obtained
6. washwas washed with a mixed solvent of diethyl ether and hexane
7. filtrationcollected by filtration