Hydrochloric Acid → HCID 23114872, compound

HRID 2080440Notes

Reaction equation

HRID 2080440 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[CH:14]=[N:15][C:16]([CH:19]([S:28]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)(=[O:30])=[O:29])[C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[F:27])=[CH:17][CH:18]=1)=[O:12])(C)(C)C.Cl>C(O)C>[NH2:7][CH2:8][CH2:9][NH:10][C:11](=[O:12])[C:13]1[CH:18]=[CH:17][C:16]([CH:19]([S:28]([C:31]2[CH:32]=[CH:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:30])=[O:29])[C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[F:27])=[N:15][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 58734276HCID 58734276, compound

Product 1

HCID 23114872HCID 23114872, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an ethanol (2 ml) solution of t-butyl[2-[[6-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridine-3-carbonyl]amino]ethyl]carbamate (50 mg, 0.0880 mmol) was added concentrated hydrochloric acid (2 ml). The resulting mixture was stirred at room temperature for 20 minutes. The reaction mixture was concentrated under reduced pressure. The solid thus obtained was washed with diethyl ether to give the title compound (44 mg, 0.0880 mmol, quant.) as 1.5 hydrochloride (white powder).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe solid thus obtained
  3. washwas washed with diethyl ether

Sources & evidence

ORD record
ord-505ef24dd681489e86d4010ca312e5ab
Source dataset
uspto-grants-2011_04
Patent number
US07932271B2

Reaction notes

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