Hydrochloric Acid → HCID 23114731, compound

HRID 2080442Notes

Reaction equation

HRID 2080442 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[CH:14]=[N:15][C:16]([CH:19]([S:28]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)(=[O:30])=[O:29])[C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[F:27])=[CH:17][CH:18]=1)=[S:12])(C)(C)C.Cl>C(O)C>[NH2:7][CH2:8][CH2:9][NH:10][C:11](=[S:12])[C:13]1[CH:18]=[CH:17][C:16]([CH:19]([S:28]([C:31]2[CH:32]=[CH:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:30])=[O:29])[C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[F:27])=[N:15][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 58734244HCID 58734244, compound

Product 1

HCID 23114731HCID 23114731, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To an ethanol (3 ml) solution of t-butyl[2-[[6-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridine-3-carbothioyl]amino]ethyl]carbamate (80 mg, 0.137 mmol) was added concentrated hydrochloric acid (2 ml). The resulting mixture was stirred at room temperature for 20 minutes. The reaction mixture was concentrated under reduced pressure. To the residue thus obtained was added ethanol, followed by concentration. This operation was conducted three times to give the title compound (76 mg, 0.137 mmol, quant.) as a 1.75 hydrochloride (yellow powder).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customTo the residue thus obtained
  3. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-32e397fa70914b7f9892352981d8e978
Source dataset
uspto-grants-2011_04
Patent number
US07932271B2

Reaction notes

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