Hydrochloride methanol → HCID 23114814, compound

HRID 2080458Notes

Reaction equation

[Cl:1][C:2]1[C:3]([CH:20]([S:29]([C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)(=[O:31])=[O:30])[C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])=[CH:4][C:5]([NH:8][CH2:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)=[N:6][CH:7]=1.[ClH:39].CO>>[ClH:1].[ClH:39].[Cl:1][C:2]1[C:3]([CH:20]([S:29]([C:32]2[CH:33]=[CH:34][C:35]([Cl:38])=[CH:36][CH:37]=2)(=[O:30])=[O:31])[C:21]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=2[F:28])=[CH:4][C:5]([NH:8][CH2:9][CH2:10][CH2:11][NH2:12])=[N:6][CH:7]=1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 23114763HCID 23114763, compound

Product 1

HCID 23114814HCID 23114814, compoundYield 83%

Procedure

To t-butyl 3-[[5-chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridin-2-yl]amino]propylcarbamate (70 mg, 0.13 mmol) was added a 20% hydrochloric acid-methanol solution (2 ml). The resulting mixture was stirred for 2 hours. The residue obtained by concentrating the reaction mixture under reduced pressure was crystallized from ethanol to give the title compound as a white solid (42 mg, 83%).

Workup

customThe residue obtained
concentrationby concentrating the reaction mixture under reduced pressure
customwas crystallized from ethanol

Sources & evidence

ORD record: ord-4c7d770b2ec0425fa48513be5887c15f
Source dataset: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07932271B2

Reaction notes

Loading…