Ammonia → HCID 67100330, compound

HRID 2080650Notes

Reaction equation

HRID 2080650 reaction equation
[NH3:1].Cl[S:3]([C:6]1[C:7]([O:26][CH3:27])=[CH:8][C:9]([O:24][CH3:25])=[C:10]([C:12]2[N:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[N:15]=[CH:14][CH:13]=2)[CH:11]=1)(=[O:5])=[O:4]>CO>[NH2:1][S:3]([C:6]1[C:7]([O:26][CH3:27])=[CH:8][C:9]([O:24][CH3:25])=[C:10]([C:12]2[N:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[N:15]=[CH:14][CH:13]=2)[CH:11]=1)(=[O:5])=[O:4]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86619516HCID 86619516, compound

Product 1

HCID 67100330HCID 67100330, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8.2 20 ml of a 32% ammonia solution are added at room temperature to a solution of 413.3 mg of “B2” in 5 ml of dry methanol. The mixture is stirred overnight, approximately half of the solvent is removed, the precipitated crystals are separated off and washed with water, giving 230 mg of 5-(5-aminosulfonyl-2,4-dimethoxyphenyl)-1-(2-chlorophenyl)-1H-pyrazole (“C1”) and, as by-product, 5-(5-hydroxysulfonyl-2,4-dimethoxyphenyl)-1-(2-chlorophenyl)-1H-pyrazole (“C2”).

Workup

  1. customapproximately half of the solvent is removed
  2. customthe precipitated crystals are separated off
  3. washwashed with water

Sources & evidence

ORD record
ord-e22de09b9fbb48f5ab21a14a49b0427d
Source dataset
uspto-grants-2011_04
Patent number
US07932401B2

Reaction notes

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