Ammonia → HCID 67100330, compound

Participants

Reaction Steps

8.2 20 ml of a 32% ammonia solution are added at room temperature to a solution of 413.3 mg of “B2” in 5 ml of dry methanol. The mixture is stirred overnight, approximately half of the solvent is removed, the precipitated crystals are separated off and washed with water, giving 230 mg of 5-(5-aminosulfonyl-2,4-dimethoxyphenyl)-1-(2-chlorophenyl)-1H-pyrazole (“C1”) and, as by-product, 5-(5-hydroxysulfonyl-2,4-dimethoxyphenyl)-1-(2-chlorophenyl)-1H-pyrazole (“C2”).

Provenance & Evidence