Hydrochloric Acid → HCID 178477646, compound

HRID 2080682Notes

Reaction equation

HRID 2080682 reaction equation
[OH-].[Na+].[CH2:3]([S:5]([C:8]1[CH:33]=[CH:32][C:11]([O:12][C:13]2[C:14]([C:28]([O:30]C)=[O:29])=[CH:15][C:16]3[N:20]=[C:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=4)[NH:18][C:17]=3[CH:27]=2)=[CH:10][CH:9]=1)(=[O:7])=[O:6])[CH3:4].Cl>>[CH2:3]([S:5]([C:8]1[CH:33]=[CH:32][C:11]([O:12][C:13]2[C:14]([C:28]([OH:30])=[O:29])=[CH:15][C:16]3[N:20]=[C:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=4)[NH:18][C:17]=3[CH:27]=2)=[CH:10][CH:9]=1)(=[O:6])=[O:7])[CH3:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178477647HCID 178477647, compound

Product 1

HCID 178477646HCID 178477646, compound

Conditions

Temperature
50 °C

Procedure

10 ml of aqueous 1 N sodium hydroxide solution was added to 2.3 g of the methyl ester compound obtained in Example 174, and the reaction liquid was stirred overnight at 50° C. 4 ml of 3 N hydrochloric acid was added to the reaction liquid, and the precipitated deposit was taken out through filtration to obtain the entitled compound.

Workup

  1. customthe reaction liquid
  2. filtrationthe precipitated deposit was taken out through filtration
  3. customto obtain the entitled compound

Sources & evidence

ORD record
ord-684fdb76e58846fea994141397cf54ed
Source dataset
uspto-grants-2011_04
Patent number
US07932394B2

Reaction notes

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