Water → HCID 57433664, compound

HRID 2080687Notes

Reaction equation

HRID 2080687 reaction equation
C(=O)([O-])[O-].[K+].[K+].O.C([O:11][CH:12]([CH2:17][CH2:18][N:19]=[N+:20]=[N-:21])[C:13]([O:15][CH3:16])=[O:14])(=O)C.[Cl-].[NH4+]>CO>[N:19]([CH2:18][CH2:17][CH:12]([OH:11])[C:13]([O:15][CH3:16])=[O:14])=[N+:20]=[N-:21]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 25517Ammonium ChlorideHCID 57433663HCID 57433663, compound

Product 1

HCID 57433664HCID 57433664, compoundYield 30.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.53 g of potassium carbonate and 1 ml of water were added to a methanol (15 ml) solution of 2.47 g of methyl 2-(acetyloxy)-4-azidobutanoate, and stirred at room temperature for 30 minutes. Aqueous saturated ammonium chloride solution was added to the reaction liquid, and extracted with ethyl acetate. The organic layer was washed with saturated saline water and dried. The solvent was evaporated away under reduced pressure to obtain 591 mg of methyl 4-azido-2-hydroxybutanoate as an orange oil.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated saline water
  3. customdried
  4. customThe solvent was evaporated away under reduced pressure

Sources & evidence

ORD record
ord-24be19ca618145779d0a62e28625b5ea
Source dataset
uspto-grants-2011_04
Patent number
US07932394B2

Reaction notes

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