反应详情

The compound (82.0 mg) obtained in Example 11-12 was dissolved in methanol (4.1 ml) and added with hydrazine monohydrate (0.082 ml) and the whole was refluxed under heating for 3 hours. The reaction solution was concentrated under reduced pressure. Then, the residue was added with water and subjected to extraction with chloroform. The organic layer was washed with a saturated saline solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (40.1 mg) as a yellow oily substance.

1. temperaturethe whole was refluxed
2. temperatureunder heating for 3 hours
3. concentrationThe reaction solution was concentrated under reduced pressure
4. additionThen, the residue was added with water
5. extractionsubjected to extraction with chloroform
6. washThe organic layer was washed with a saturated saline solution
7. dry with materialdried with anhydrous sodium sulfate
8. concentrationconcentrated under reduced pressure
9. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)