HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2080754Generated: October 30, 2026
Water → 2-(1-methyl-1H-imidazol-2-ylmethyl)-isoindol-1,3-dione
https://huagongshe.com/reaction/2080754
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride | HCID 2795406 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | Phthalimide potassium salt | HCID 24194345 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(1-methyl-1H-imidazol-2-ylmethyl)-isoindol-1,3-dione | HCID 23155421 | 84.2% |
Reaction Steps
The compound (83.50 g) obtained in Example 10-2 was suspended in DMF (250 ml) and added with sodium t-butoxide (49.00 g) at −30° C. The solution was further added with a potassium phthalimide salt (95.0 g) and then the whole was stirred at 70° C. for 2 hours. After completion of the reaction, the resultant was added into water (800 ml). The precipitated crystal was filtrated, washed with water, and dried, thereby obtaining the subject compound (101.5 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932281B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-939b6bbf0f5a4400919cd7731713f4de |
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| Source note | uspto-grants-2011_04 |
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