反应详情

The compound (2.23 g) obtained in Example 17-2 was dissolved in NMP (27 ml) and added with cuprous cyanide (1.56 g) and the whole was refluxed under heating for 4 hours. After completion of the reaction, the whole was cooled with ice and added with water and ammonium water. The resultant was subjected to extraction with chloroform and dried with magnesium sulfate. The solvent was distilled off under reduced pressure. The resultant was dissolved in diethyl ether and added with a 4 mol/l hydrogen chloride/dioxane solution. The precipitate was filtrated and washed with diethylether. The resultant was dried under heating, thereby obtaining a hydrochloride (1.95 g) of the subject compound as a brown solid.

1. temperaturethe whole was refluxed
2. temperatureunder heating for 4 hours
3. customAfter completion of the reaction
4. temperaturethe whole was cooled with ice
5. extractionThe resultant was subjected to extraction with chloroform
6. dry with materialdried with magnesium sulfate
7. distillationThe solvent was distilled off under reduced pressure
8. dissolutionThe resultant was dissolved in diethyl ether
9. additionadded with a 4 mol/l hydrogen chloride/dioxane solution
10. filtrationThe precipitate was filtrated
11. washwashed with diethylether
12. customThe resultant was dried
13. temperatureunder heating