反应详情

In DMF (12.5 ml), 3-bromomethyl benzoic acid methyl ester (831 mg) was dissolved. The solution was added with dipropylamine (971 μl) and the whole was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform and washed with a saturated aqueous sodium hydrogen carbonate solution, followed by extraction with chloroform. The organic layer was washed with a saturated saline solution and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure, thereby obtaining the subject compound (858 mg) as a brown solid.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off under reduced pressure
3. dissolutionThe residue was dissolved in chloroform
4. washwashed with a saturated aqueous sodium hydrogen carbonate solution
5. extractionfollowed by extraction with chloroform
6. washThe organic layer was washed with a saturated saline solution
7. dry with materialdried with anhydrous sodium sulfate
8. filtrationAfter filtration
9. distillationthe solvent was distilled off under reduced pressure