反应详情

4-Bromomethylbenzoic acid methyl ester (831 mg) was dissolved in DMF (12.5 ml) and added with dipropylamine (971 μl) and the whole was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform, washed with a saturated aqueous sodium hydrogen carbonate solution, and subjected to extraction with chloroform. The organic layer was washed with a saturated saline solution and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off, thereby obtaining the subject compound (883 mg) as a brown solid.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off under reduced pressure
3. dissolutionThe residue was dissolved in chloroform
4. washwashed with a saturated aqueous sodium hydrogen carbonate solution
5. extractionsubjected to extraction with chloroform
6. washThe organic layer was washed with a saturated saline solution
7. dry with materialdried with anhydrous sodium sulfate
8. filtrationAfter filtration
9. distillationthe solvent was distilled off