Ethyl bromopyruvate → HCID 83966596, compound

HRID 2080798Notes

Reaction equation

HRID 2080798 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1.[CH2:10]([O:12][C:13](=[O:18])[C:14](=O)[CH2:15]Br)[CH3:11]>C(O)C>[CH2:10]([O:12][C:13]([C:14]1[N:1]=[C:2]2[CH:3]=[CH:4][C:5]([CH:8]=[O:9])=[CH:6][N:7]2[CH:15]=1)=[O:18])[CH3:11]

Participants

4

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 184046346-Aminopyridine-3-carbaldehyde

Product 1

HCID 83966596HCID 83966596, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

An ethanol solution (8.0 ml) containing the compound (318 mg) obtained in Example 30-1 was added with 3-bromo-2-oxo-propionic acid ethyl ester (0.33 ml) and the whole was stirred at room temperature for 18 hours. The solvent was distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (230 mg) as a yellow solid.

Workup

  1. distillationThe solvent was distilled off
  2. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

Sources & evidence

ORD record
ord-998e8314bff24073a553e1f6d7dfe2ea
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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