反应详情

温度

80 °C

4-Methylphenylboronic acid (1.00 g), 2,6-dichloropyridine (3.27 g), tetrakis(triphenylphosphine)palladium(0) (0.255 g) and potassium phosphate (3.12 g) were dissolved in toluene (35 ml) and water (6.0 ml). The mixture was stirred at 80° C. for 15 hours under a nitrogen atmosphere. The organic layer was separated, washed with a saturated aqueous sodium hydrogen carbonate solution, and dried with anhydrous magnesium sulfate and the solvent was distilled off. The resultant was crudely purified through silica gel column chromatography (chloroform), thereby obtaining a mixture (4.02 g) containing the subject compound.

1. customThe organic layer was separated
2. washwashed with a saturated aqueous sodium hydrogen carbonate solution
3. dry with materialdried with anhydrous magnesium sulfate
4. distillationthe solvent was distilled off
5. customThe resultant was crudely purified through silica gel column chromatography (chloroform)