反应详情

The mixture (5.72 g) obtained in Example 36-2 and potassium phthalimide (2.04 g) were dissolved in DMF (30 ml) and the whole was stirred at room temperature for 24 hours. Then, a solid component was separated by filtration. After the solvent was distilled off, the resultant was dissolved in chloroform and washed with a aqueous sodium hydrogen carbonate solution. The aqueous layer was extracted with chloroform and dried with anhydrous magnesium sulfate. The solvent was distilled off. The resultant residue was purified through silica gel column chromatography (chloroform), thereby obtaining the subject compound (1.56 g) as a colorless solid.

1. customThen, a solid component was separated by filtration
2. distillationAfter the solvent was distilled off
3. dissolutionthe resultant was dissolved in chloroform
4. washwashed with a aqueous sodium hydrogen carbonate solution
5. extractionThe aqueous layer was extracted with chloroform
6. dry with materialdried with anhydrous magnesium sulfate
7. distillationThe solvent was distilled off
8. customThe resultant residue was purified through silica gel column chromatography (chloroform)