Hydrochloric Acid → HCID 11591930, compound

HRID 2080837Notes

Reaction equation

HRID 2080837 reaction equation
C[O:2][C:3](=[O:40])[CH2:4][CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][N:33]([CH2:37][CH2:38][CH3:39])[CH2:34][CH2:35][CH3:36])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:16][C:17]2[N:18]([CH3:22])[CH:19]=[CH:20][N:21]=2)=[CH:10][CH:9]=1.Cl>CO>[CH2:37]([N:33]([CH2:34][CH2:35][CH3:36])[CH2:32][CH2:31][CH2:30][CH2:29][N:6]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:16][C:17]2[N:18]([CH3:22])[CH:19]=[CH:20][N:21]=2)=[CH:10][CH:9]=1)[CH2:5][CH2:4][C:3]([OH:40])=[O:2])[CH2:38][CH3:39]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11599263HCID 11599263, compound

Product 1

HCID 11591930HCID 11591930, compoundYield 56.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound (129 mg) obtained in Example 34-3 was dissolved in anhydrous methanol (1.0 ml) and added with concentrated hydrochloric acid (10.0 ml) and the whole was refluxed under heating. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (71.4 mg) of the subject compound as a pale-yellow solid.

Workup

  1. temperaturethe whole was refluxed
  2. temperatureunder heating
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-748a4b1eb84a4507a4588d6f7c9a456a
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

Loading…