Hydrochloric Acid → [(4-{[(1-carboxymethyl-1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzyl)-(4-dipropylamino-butyl)amino]-acetic acid

HRID 2080841Notes

Reaction equation

HRID 2080841 reaction equation
C[O:2][C:3](=[O:44])[CH2:4][N:5]([CH2:33][CH2:34][CH2:35][CH2:36][N:37]([CH2:41][CH2:42][CH3:43])[CH2:38][CH2:39][CH3:40])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]([CH2:22][C:23]2[N:24]([CH2:28][C:29]([O:31]C)=[O:30])[CH:25]=[CH:26][N:27]=2)[CH2:15][C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=2)=[CH:9][CH:8]=1.Cl>O1CCOCC1>[C:29]([CH2:28][N:24]1[CH:25]=[CH:26][N:27]=[C:23]1[CH2:22][N:14]([CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][N:5]([CH2:4][C:3]([OH:44])=[O:2])[CH2:33][CH2:34][CH2:35][CH2:36][N:37]([CH2:41][CH2:42][CH3:43])[CH2:38][CH2:39][CH3:40])=[CH:8][CH:9]=1)[CH2:15][C:16]1[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=1)([OH:31])=[O:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67103883[(4-dipropylamino-butyl)-(4-{[(1-methoxycarbonylmethyl-1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzyl)-amino]-acetic acid methyl ester

Product 1

HCID 58345785[(4-{[(1-carboxymethyl-1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzyl)-(4-dipropylamino-butyl)amino]-acetic acidYield 76.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (23.7 mg) obtained in Example 54-1 was dissolved in 1,4-dioxane (1.0 ml) and added with concentrated hydrochloric acid (1.0 ml) and the whole was refluxed under heating for 4 hours. After completion of the reaction, the solvent was distilled off under reduced pressure, thereby obtaining a hydrochloride (17.2 mg) of the subject compound as a yellow solid.

Workup

  1. temperaturethe whole was refluxed
  2. temperatureunder heating for 4 hours
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-1afa4043dfb94324a99edc684f566a6e
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

Loading…