HRID2080841

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCCN(CCC)CCCCN(CC(=O)OC)Cc1ccc(CN(Cc2nccn2C)Cc2nccn2CC(=O)OC)cc1

HCID67103883

未命名化合物

PRODUCTS

生成物

结构：CCCN(CCC)CCCCN(CC(=O)O)Cc1ccc(CN(Cc2nccn2C)Cc2nccn2CC(=O)O)cc1

HCID58345785

未命名化合物

收率 76.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

The compound (23.7 mg) obtained in Example 54-1 was dissolved in 1,4-dioxane (1.0 ml) and added with concentrated hydrochloric acid (1.0 ml) and the whole was refluxed under heating for 4 hours. After completion of the reaction, the solvent was distilled off under reduced pressure, thereby obtaining a hydrochloride (17.2 mg) of the subject compound as a yellow solid.

WORKUP

后处理

temperaturethe whole was refluxed
temperatureunder heating for 4 hours
customAfter completion of the reaction
distillationthe solvent was distilled off under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1afa4043dfb94324a99edc684f566a6e
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07932281B2
来源说明: uspto-grants-2011_04

反应 SMILES

C[O:2][C:3](=[O:44])[CH2:4][N:5]([CH2:33][CH2:34][CH2:35][CH2:36][N:37]([CH2:41][CH2:42][CH3:43])[CH2:38][CH2:39][CH3:40])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]([CH2:22][C:23]2[N:24]([CH2:28][C:29]([O:31]C)=[O:30])[CH:25]=[CH:26][N:27]=2)[CH2:15][C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=2)=[CH:9][CH:8]=1.Cl>O1CCOCC1>[C:29]([CH2:28][N:24]1[CH:25]=[CH:26][N:27]=[C:23]1[CH2:22][N:14]([CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][N:5]([CH2:4][C:3]([OH:44])=[O:2])[CH2:33][CH2:34][CH2:35][CH2:36][N:37]([CH2:41][CH2:42][CH3:43])[CH2:38][CH2:39][CH3:40])=[CH:8][CH:9]=1)[CH2:15][C:16]1[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=1)([OH:31])=[O:30]