Hydrochloric Acid → HCID 11613328, compound

HRID 2080850Notes

Reaction equation

HRID 2080850 reaction equation
C[O:2][C:3](=[O:39])[CH2:4][CH2:5][N:6]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH2:33][C:34]2[NH:35][CH:36]=[CH:37][N:38]=2)[CH2:26][C:27]2[N:28]([CH3:32])[CH:29]=[CH:30][N:31]=2)=[CH:20][CH:19]=1)[CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.Cl>O>[NH:38]1[CH:37]=[CH:36][N:35]=[C:34]1[CH2:33][N:25]([CH2:24][C:21]1[CH:20]=[CH:19][C:18]([CH2:17][N:6]([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:5][CH2:4][C:3]([OH:39])=[O:2])=[CH:23][CH:22]=1)[CH2:26][C:27]1[N:28]([CH3:32])[CH:29]=[CH:30][N:31]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67103666HCID 67103666, compound

Product 1

HCID 11613328HCID 11613328, compoundYield 103.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound (333 mg) obtained in Example 62-3 was dissolved in water (0.5 ml) and concentrated hydrochloric acid (6.0 ml) and the whole was refluxed under heating for 2 hours. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (336 mg) of the subject compound as a white solid.

Workup

  1. temperatureunder heating for 2 hours
  2. customAfter completion of the reaction
  3. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-1df8683bcd704c5abcb7c48dc982d835
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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