Hydrochloric Acid → [(4-dipropylamino-butyl)-(4-[[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl]-benzyl)-amino]-acetic acid

HRID 2080853Notes

Reaction equation

HRID 2080853 reaction equation
Cl.C[O:3][C:4](=[O:40])[CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][N:33]([CH2:37][CH2:38][CH3:39])[CH2:34][CH2:35][CH3:36])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:16][C:17]2[N:18]([CH3:22])[CH:19]=[CH:20][N:21]=2)=[CH:10][CH:9]=1>>[CH2:37]([N:33]([CH2:34][CH2:35][CH3:36])[CH2:32][CH2:31][CH2:30][CH2:29][N:6]([CH2:5][C:4]([OH:40])=[O:3])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:16][C:17]2[N:18]([CH3:22])[CH:19]=[CH:20][N:21]=2)=[CH:10][CH:9]=1)[CH2:38][CH3:39]

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 11526689[(4-dipropylamino-butyl)-(4-[[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl]-benzyl)-amino]-acetic acid methyl ester

Product 1

HCID 11540944[(4-dipropylamino-butyl)-(4-[[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl]-benzyl)-amino]-acetic acid

Procedure

The hydrochloride (30.8 mg) of the compound obtained in Example 64-2 was added with concentrated hydrochloric acid (3.00 ml) and the whole was refluxed under heating. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (30.5 mg) of the subject compound as a white solid.

Workup

  1. temperaturethe whole was refluxed
  2. temperatureunder heating
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-4ea7081092aa49948a3ceeec14dbf228
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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