HRID2080853

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

2 次

结构：CCCN(CCC)CCCCN(CC(=O)OC)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1

HCID11526689

未命名化合物

PRODUCTS

生成物

结构：CCCN(CCC)CCCCN(CC(=O)O)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1

HCID11540944

未命名化合物

PROCEDURE

实验过程

The hydrochloride (30.8 mg) of the compound obtained in Example 64-2 was added with concentrated hydrochloric acid (3.00 ml) and the whole was refluxed under heating. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (30.5 mg) of the subject compound as a white solid.

WORKUP

后处理

temperaturethe whole was refluxed
temperatureunder heating
customAfter completion of the reaction
distillationthe solvent was distilled off

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4ea7081092aa49948a3ceeec14dbf228
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07932281B2
来源说明: uspto-grants-2011_04

反应 SMILES

Cl.C[O:3][C:4](=[O:40])[CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][N:33]([CH2:37][CH2:38][CH3:39])[CH2:34][CH2:35][CH3:36])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:16][C:17]2[N:18]([CH3:22])[CH:19]=[CH:20][N:21]=2)=[CH:10][CH:9]=1>>[CH2:37]([N:33]([CH2:34][CH2:35][CH3:36])[CH2:32][CH2:31][CH2:30][CH2:29][N:6]([CH2:5][C:4]([OH:40])=[O:3])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:16][C:17]2[N:18]([CH3:22])[CH:19]=[CH:20][N:21]=2)=[CH:10][CH:9]=1)[CH2:38][CH3:39]