Hydrochloric Acid → HCID 11670688, compound

HRID 2080855Notes

Reaction equation

HRID 2080855 reaction equation
C[O:2][C:3](=[O:38])[CH2:4][N:5]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH2:32][C:33]2[NH:34][CH:35]=[CH:36][N:37]=2)[CH2:26][C:27]2[NH:28][CH:29]=[CH:30][N:31]=2)=[CH:20][CH:19]=1)[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13].Cl>O>[NH:28]1[CH:29]=[CH:30][N:31]=[C:27]1[CH2:26][N:25]([CH2:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:5]([CH2:4][C:3]([OH:38])=[O:2])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13])=[CH:19][CH:20]=1)[CH2:32][C:33]1[NH:37][CH:36]=[CH:35][N:34]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11533761HCID 11533761, compound

Product 1

HCID 11670688HCID 11670688, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound (533.4 mg) obtained in Example 68-1 was dissolved in water (0.5 ml) and added with concentrated hydrochloric acid (2.5 ml). The whole was refluxed under heating for 30 minutes. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (384.1 mg) of the subject compound as a white solid.

Workup

  1. temperatureThe whole was refluxed
  2. temperatureunder heating for 30 minutes
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-4da547024b0c4f808c8a0afcbe4ccb63
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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