HCID 67103541, compound → HCID 11649532, compound

HRID 2080872Notes

Reaction equation

HRID 2080872 reaction equation
C[O:2][C:3](=[O:40])[CH2:4][N:5]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH2:33][C:34]2[N:35]([CH3:39])[CH:36]=[CH:37][N:38]=2)[CH2:26][C:27]2[N:28]([CH3:32])[CH:29]=[CH:30][N:31]=2)=[CH:20][CH:19]=1)[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13]>Cl>[CH3:39][N:35]1[CH:36]=[CH:37][N:38]=[C:34]1[CH2:33][N:25]([CH2:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:5]([CH2:4][C:3]([OH:40])=[O:2])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13])=[CH:19][CH:20]=1)[CH2:26][C:27]1[N:28]([CH3:32])[CH:29]=[CH:30][N:31]=1

Participants

3

Reactant 1

HCID 67103541HCID 67103541, compound

Product 1

HCID 11649532HCID 11649532, compoundYield 130.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

The compound (36.8 mg) obtained in Example 81-1 was dissolved in concentrated hydrochloric acid (1.0 ml) and the whole was stirred at 100° C. for 1 hour. After completion of the reaction, the solution was concentrated and dried under vacuum, thereby obtaining a hydrochloride (46.8 mg) of the subject compound as a white solid.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe solution was concentrated
  3. customdried under vacuum

Sources & evidence

ORD record
ord-2ab1084d685e4c72ae0867e907ce677d
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

Loading…