Hydrochloric Acid → HCID 11663826, compound

HRID 2080878Notes

Reaction equation

HRID 2080878 reaction equation
C([O:3][C:4](=[O:41])[CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][N:12]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][N:28]([CH2:30][CH2:31][CH2:32][CH2:33][N:34]([CH2:38][CH2:39][CH3:40])[CH2:35][CH2:36][CH3:37])[CH3:29])=[CH:23][CH:22]=1)[CH2:13][C:14]1[N:15]([CH3:19])[CH:16]=[CH:17][N:18]=1)C.Cl>O1CCOCC1>[CH2:38]([N:34]([CH2:35][CH2:36][CH3:37])[CH2:33][CH2:32][CH2:31][CH2:30][N:28]([CH2:27][C:24]1[CH:23]=[CH:22][C:21]([CH2:20][N:12]([CH2:11][C:7]2[N:6]([CH2:5][C:4]([OH:41])=[O:3])[CH:10]=[CH:9][N:8]=2)[CH2:13][C:14]2[N:15]([CH3:19])[CH:16]=[CH:17][N:18]=2)=[CH:26][CH:25]=1)[CH3:29])[CH2:39][CH3:40]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67103557HCID 67103557, compound

Product 1

HCID 11663826HCID 11663826, compoundYield 199.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

The compound (41.6 mg) obtained in Example 87-1 was dissolved in dioxane (0.80 ml) and added with concentrated hydrochloric acid (800 μl) at room temperature and the whole was stirred at an outside temperature of 100° C. for 5 hours. After completion of the reaction, the resultant was concentrated and evaporated to dryness under reduced pressure, thereby obtaining a hydrochloride (78.7 mg) of the subject compound as a white solid.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe resultant was concentrated
  3. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-54e0aec1059a4474831301645b2b4f0d
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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