5-dipropylamino-(2S)-[(4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzyl)-methyl-amino]-pentanoic acid ethyl ester → 5-dipropylamino-(2S)-[(4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzyl)-methyl-amino]-pentanoic acid

HRID 2080891Notes

Reaction equation

C([O:3][C:4](=[O:40])[C@@H:5]([N:16]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][N:26]([CH2:34][C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)[CH2:27][C:28]2[N:29]([CH3:33])[CH:30]=[CH:31][N:32]=2)=[CH:21][CH:20]=1)[CH3:17])[CH2:6][CH2:7][CH2:8][N:9]([CH2:13][CH2:14][CH3:15])[CH2:10][CH2:11][CH3:12])C>Cl>[CH2:13]([N:9]([CH2:10][CH2:11][CH3:12])[CH2:8][CH2:7][CH2:6][C@H:5]([N:16]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][N:26]([CH2:34][C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)[CH2:27][C:28]2[N:29]([CH3:33])[CH:30]=[CH:31][N:32]=2)=[CH:21][CH:20]=1)[CH3:17])[C:4]([OH:40])=[O:3])[CH2:14][CH3:15]

Participants

Conditions

Temperature: 100 °C

Procedure

The compound (42.9 mg) obtained in Example 92-4 was dissolved in concentrated hydrochloric acid (1.0 ml) and the whole was stirred at 100° C. for 5 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and the residue was dried under vacuum, thereby obtaining a hydrochloride (52.3 mg) of the subject compound as a white solid.

Workup

customAfter completion of the reaction
distillationthe solvent was distilled off under reduced pressure
customthe residue was dried under vacuum

Sources & evidence

ORD record: ord-8d6f33936130412f9f54a94b1b9f6eb3
Source dataset: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07932281B2

Reaction notes

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