HCID 11570292, compound → HCID 11649360, compound

HRID 2080892Notes

Reaction equation

HRID 2080892 reaction equation
C([O:3][C:4](=[O:40])[C@@H:5]([N:33]([CH2:37][CH2:38][CH3:39])[CH2:34][CH2:35][CH3:36])[CH2:6][CH2:7][CH2:8][N:9]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][N:19]([CH2:27][C:28]2[NH:29][CH:30]=[CH:31][N:32]=2)[CH2:20][C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[CH:14][CH:13]=1)[CH3:10])C>Cl>[CH2:34]([N:33]([C@@H:5]([CH2:6][CH2:7][CH2:8][N:9]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([CH2:18][N:19]([CH2:27][C:28]2[NH:29][CH:30]=[CH:31][N:32]=2)[CH2:20][C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[CH:16][CH:17]=1)[CH3:10])[C:4]([OH:40])=[O:3])[CH2:37][CH2:38][CH3:39])[CH2:35][CH3:36]

Participants

3

Reactant 1

HCID 11570292HCID 11570292, compound

Product 1

HCID 11649360HCID 11649360, compoundYield 104.7%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

The compound (33.0 mg) obtained in Example 94-2 was dissolved in concentrated hydrochloric acid (1.0 ml) and the whole was stirred at 100° C. for 5 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and the residue was dried under vacuum, thereby obtaining a hydrochloride (32.8 mg) of the subject compound as a white solid.

Workup

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-043e233433c14ac599395c94e6bed17c
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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