HCID 11649703, compound → HCID 11497341, compound

HRID 2080897Notes

Reaction equation

HRID 2080897 reaction equation
C([O:3][C:4](=[O:40])[CH:5]([N:27]([CH2:29][CH2:30][CH2:31][CH2:32][N:33]([CH2:37][CH2:38][CH3:39])[CH2:34][CH2:35][CH3:36])[CH3:28])[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]([CH2:21][C:22]2[NH:23][CH:24]=[CH:25][N:26]=2)[CH2:14][C:15]2[N:16]([CH3:20])[CH:17]=[CH:18][N:19]=2)=[CH:8][CH:7]=1)C>Cl>[CH2:37]([N:33]([CH2:34][CH2:35][CH3:36])[CH2:32][CH2:31][CH2:30][CH2:29][N:27]([CH:5]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]([CH2:21][C:22]2[NH:23][CH:24]=[CH:25][N:26]=2)[CH2:14][C:15]2[N:16]([CH3:20])[CH:17]=[CH:18][N:19]=2)=[CH:8][CH:7]=1)[C:4]([OH:40])=[O:3])[CH3:28])[CH2:38][CH3:39]

Participants

3

Reactant 1

HCID 11649703HCID 11649703, compound

Product 1

HCID 11497341HCID 11497341, compoundYield 123.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

The compound (5.1 mg) obtained in Example 100-2 was dissolved in concentrated hydrochloric acid (204 μl) and the whole was refluxed at 100° C. for 20 hours. After completion of the reaction, the solvent was distilled off, thereby obtaining the subject compound (6.0 mg) as a white solid.

Workup

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-e37a83c00d54479d8e76f39e74d229fe
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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