Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-{[(4-dipropylamino-butyl)-methyl-amino]-methyl}-5-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzoic acid ethyl ester | HCID 11642487 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 11577272 | HCID 11577272 | 127.5% |
Reaction Steps
The compound (5.7 mg) obtained in Example 102-5 was suspended in distilled water (30 μl). The reaction solution was added with concentrated hydrochloric acid (100 μl) and the whole was stirred at 80° C. for 19 hours. After having been cooled to room temperature, the reaction solution was concentrated under reduced pressure, thereby obtaining the subject compound (6.9 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932281B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-0f67ae8a941e40febc07dc5ef92ede42 |
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| Source note | uspto-grants-2011_04 |
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