Hydrochloric Acid → HCID 11577272, compound

HRID 2080901Notes

Reaction equation

HRID 2080901 reaction equation
C([O:3][C:4](=[O:40])[C:5]1[CH:10]=[C:9]([CH2:11][N:12]([CH2:20][C:21]2[NH:22][CH:23]=[CH:24][N:25]=2)[CH2:13][C:14]2[N:15]([CH3:19])[CH:16]=[CH:17][N:18]=2)[CH:8]=[CH:7][C:6]=1[CH2:26][N:27]([CH2:29][CH2:30][CH2:31][CH2:32][N:33]([CH2:37][CH2:38][CH3:39])[CH2:34][CH2:35][CH3:36])[CH3:28])C.Cl>O>[CH2:37]([N:33]([CH2:34][CH2:35][CH3:36])[CH2:32][CH2:31][CH2:30][CH2:29][N:27]([CH2:26][C:6]1[CH:7]=[CH:8][C:9]([CH2:11][N:12]([CH2:20][C:21]2[NH:22][CH:23]=[CH:24][N:25]=2)[CH2:13][C:14]2[N:15]([CH3:19])[CH:16]=[CH:17][N:18]=2)=[CH:10][C:5]=1[C:4]([OH:40])=[O:3])[CH3:28])[CH2:38][CH3:39]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 116424872-{[(4-dipropylamino-butyl)-methyl-amino]-methyl}-5-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzoic acid ethyl ester

Product 1

HCID 11577272HCID 11577272, compoundYield 127.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

The compound (5.7 mg) obtained in Example 102-5 was suspended in distilled water (30 μl). The reaction solution was added with concentrated hydrochloric acid (100 μl) and the whole was stirred at 80° C. for 19 hours. After having been cooled to room temperature, the reaction solution was concentrated under reduced pressure, thereby obtaining the subject compound (6.9 mg) as a white solid.

Workup

  1. temperatureAfter having been cooled to room temperature
  2. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0f67ae8a941e40febc07dc5ef92ede42
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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