反应详情

A solution of 1,1-dimethylethyl 4-{4-[({[2-chloro-3-(trifluoromethyl)phenyl]methyl}amino)carbonyl]-3-methyl-2-oxo-1-imidazolidinyl}-1-piperidinecarboxylate (218 mg, 0.42 mmol) in 1,4-dioxane (3 ml) was treated with 4M hydrogen chloride in 1,4-dioxane (1 ml) and the reaction was stirred at room temperature for 4 hours. The solvent was evaporated and the gum was dissolved in methanol and the solvent evaporated. The residue was triturated with ether and the solid was collected and dried to give N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-3-methyl-2-oxo-1-(4-piperidinyl)-4-imidazolidinecarboxamide hydrochloride (153 mg, 80%), LC/MS [M+H]+=419, retention time=1.75 minutes.

1. customThe solvent was evaporated
2. dissolutionthe gum was dissolved in methanol
3. customthe solvent evaporated
4. customThe residue was triturated with ether
5. customthe solid was collected
6. customdried