反应详情

A mixture of 3-methyl-1-(2-methyl-3-pyridinyl)-2-oxo-4-imidazolidinecarboxylic acid TFA salt (279 mg, 0.8 mmol), 1-hydroxybenzotriazole hydrate (147 mg, 0.96 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (184 mg, 0.96 mmol) and N-ethyl morpholine (0.613 ml, 4.8 mmol) in dichloromethane (18 ml) was stirred at room temperature for 10 minutes. A solution of [1-(2,4-dichlorophenyl)methyl]amine (141 mg, 0.8 mmol) in dichloromethane (2 ml) was added and the reaction stirred at room temperature for 4 hours. The mixture was partitioned between dichloromethane and saturated sodium hydrogen carbonate solution. The organic phase was separated, washed with water and brine, dried and evaporated. The residue was purified by silica gel chromatography eluting with 0-10% methanol in dichloromethane to give N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-(2-methyl-3-pyridinyl)-2-oxo-4-imidazolidinecarboxamide (147 mg, 47%). LC/MS [M+H]+=393, retention time=1.76 minutes.

1. stirringthe reaction stirred at room temperature for 4 hours
2. customThe mixture was partitioned between dichloromethane and saturated sodium hydrogen carbonate solution
3. customThe organic phase was separated
4. washwashed with water and brine
5. customdried
6. customevaporated
7. customThe residue was purified by silica gel chromatography
8. washeluting with 0-10% methanol in dichloromethane