反应详情

温度

140 °C

Ammonia gas was bubbled into a solution of 4-chloro-3-{5-[5-(4-chloro-benzyl)-[1,3,4]oxadiazol-2-yl]-2-methyl-phenoxymethyl}-thieno[3,2-c]pyridine-7-carboxylic acid ethyl ester (0.11 g, 0.20 mmol) (from Example 41 supra) in 2-propanol (15 mL) for 20 min. The mixture was heated in a microwave reactor at 140° C. for 5.5 hours. The reaction mixture was concentrated. The residue was washed with hot methanol, filtered and dried to give 4-amino-3-{5-[5-(4-chloro-benzyl)-[1,3,4]oxadiazol-2-yl]-2-methyl-phenoxymethyl}-thieno[3,2-c]pyridine-7-carboxylic acid ethyl ester. (Yield 0.07 g, 64%).

1. concentrationThe reaction mixture was concentrated
2. washThe residue was washed with hot methanol
3. filtrationfiltered
4. customdried