HCID 70324238, compound → HCID 53465517, compound

HRID 2081137Notes

Reaction equation

HRID 2081137 reaction equation
[CH:1]1([S:4]([NH:7][C:8]([C@@:10]2([NH:15]C(=O)OC(C)(C)C)[CH2:12][C@H:11]2[CH2:13][CH3:14])=[O:9])(=[O:6])=[O:5])[CH2:3][CH2:2]1>Cl.O1CCOCC1>[NH2:15][C@:10]1([C:8]([NH:7][S:4]([CH:1]2[CH2:3][CH2:2]2)(=[O:6])=[O:5])=[O:9])[CH2:12][C@H:11]1[CH2:13][CH3:14]

Participants

4

Reactant 1

HCID 70324238HCID 70324238, compound

Product 1

HCID 53465517HCID 53465517, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

Tert-butyl (1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropylcarbamate (0.53 g, 1.60 mmol) was dissolved in 4 N HCl in dioxane (20 mL) and stirred at rt for 5 hour. Removal of solvent gave (1R,2R)-1-amino-N-(cyclopropylsulfonyl)-2-ethylcyclopropanecarboxamide dihydrchloride as a white foamy solid. It was used directly in the next step without further purification.

Workup

  1. customRemoval of solvent

Sources & evidence

ORD record
ord-a32b579d5b124ac68ad60fc42fc5e09e
Source dataset
uspto-grants-2011_04
Patent number
US07932277B2

Reaction notes

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