Diphosgene → HCID 19780807, compound

Participants

Reaction Steps

A solution of 40 g of diphosgene in 150 ml of ethyl acetate is heated to 65° C. while stirring. To this solution is added dropwise a solution of 40 g of ethyl 2-(5-amino-2-chloro-benzoyloxy)-2-methyl-propionate in 70 ml of ethyl acetate. After completion of the addition the reaction mixture is heated to reflux temperature for 3 hours. Thereafter, the solvent is distilled off. The residue is distilled in a bulb-tube at 200°-230° C. and 0.1 torr. In this manner there is obtained ethyl 2-(2-chloro-5-isocyanato-benzoyloxy)-2-methyl-propionate,

Provenance & Evidence