4-Fluoroaniline → HCID 19799249, compound

HRID 2081192Notes

Reaction equation

HRID 2081192 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[O:9]=[C:10]1[CH2:15][C:14](=O)[CH2:13][CH2:12][NH:11]1>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:14]2[CH2:13][CH2:12][NH:11][C:10](=[O:9])[CH:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 108878632,4-Piperidinedione

Product 1

HCID 19799249HCID 19799249, compoundYield 94.2%

Procedure

A mixture of 4-fluoroaniline (978 mg) and 2,4-dioxopiperidine (1.0 g) was heated at 120° for 1 h, and then cooled. The solid was triturated with ether (30 ml) and the solvent was decanted to leave the title compound (1.71 g), m.p. 195°-198°.

Workup

  1. temperaturewas heated at 120° for 1 h
  2. temperaturecooled
  3. customThe solid was triturated with ether (30 ml)
  4. customthe solvent was decanted

Sources & evidence

ORD record
ord-b162d8ce95414641a0f59924eceafe9c
Source dataset
uspto-grants-1993_02
Patent number
US05183820

Reaction notes

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