O-Toluidine → HCID 15712495, compound

HRID 2081193Notes

Reaction equation

HRID 2081193 reaction equation
[NH2:1][C:2]1[C:3]([CH3:8])=[CH:4][CH:5]=[CH:6][CH:7]=1.[O:9]=[C:10]1[CH2:15][C:14](=O)[CH2:13][CH2:12][NH:11]1>>[CH3:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:14]1[CH2:13][CH2:12][NH:11][C:10](=[O:9])[CH:15]=1

Participants

3

Reactant 2

HCID 7242O-ToluidineHCID 108878632,4-Piperidinedione

Product 1

HCID 15712495HCID 15712495, compoundYield 97.8%

Procedure

A mixture of o-toluidine (943 mg) and 2,4-dioxopiperidine (1.0 g) was heated at 120° for 30 min. The oil was cooled, triturated with ether (30 ml) and the solvent was decanted to give the title compound (1.74 g), m.p. 155°-158°.

Workup

  1. temperaturewas heated at 120° for 30 min
  2. temperatureThe oil was cooled
  3. customtriturated with ether (30 ml)
  4. customthe solvent was decanted

Sources & evidence

ORD record
ord-98d87b973b42465abb12b8a171a1ed2d
Source dataset
uspto-grants-1993_02
Patent number
US05183820

Reaction notes

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